Background:
Thrombotic Thrombocytopenic Purpura (TTP) is a serious but rare differential for thrombocytopenia in pregnancy and poses a significant morbidity and mortality burden to the maternofetal dyad.1 The presence of comorbid thrombotic microangiopathies, such as TTP and systemic lupus erythematosus (SLE) have been increasingly commented upon, in case reports, over the past decade, albeit a rare clinical presentation. The occurrence of this during the antepartum period adds another factor of complexity.
Case presentation:
We present an atypical case of a successful pregnancy outcome in a 28-year-old female, following diagnosis of TTP at 35 weeks, in the context of previously well-controlled SLE, on a background history of preeclampsia and haemolysis - elevated liver enzymes - low platelet (HELLP) syndrome.
Conclusion:
The diagnosis of TTP in pregnancy is challenging due to its nonspecific clinical presentation and the potential for overlap with other pregnancy-related pathologies.2 Correct diagnosis, timely intervention and a tertiary multidisciplinary approach is crucial to achieving positive outcomes. Nonetheless, further research, case presentation and collation of findings, is required to more clearly define presentation, prognosis, and treatment regimens for this life-threatening clinical syndrome.