Background
Bartter’s and Gitelman’s syndromes are rare genetic conditions characterised by renal sodium and potassium wasting. Pregnancy is a time of heightened risk for affected patients with the increased potassium and magnesium demands of pregnancy often leading to severe hypokalaemia and hypomagnesaemia with the potential for adverse outcomes. There are no published guidelines for the management of these conditions in pregnancy and a wide range of management strategies have been reported in published studies. The ideal management of these conditions in pregnancy remains unknown.
Aim
To conduct a systematic review of all published literature on maternal Bartter's and Gitelman's syndromes.
Methods
A literature search was conducted of PubMed, EMBASE, and The Cochrane Library - CENTRAL databases without exclusions through June 2023. 557 studies were identified in the initial search and after the removal of duplicates, 328 studies received title and abstract screening. Studies including reports of maternal Bartter’s syndrome and maternal Gitelman’s syndrome were included for further analysis. 75 full-text studies were reviewed for eligibility and 59 articles were included for final analysis.
Results
Data reported from this systematic review will include maternal characteristics, pre-pregnancy, and pregnancy management; timing and mode of delivery; maternal and neonatal outcomes.